myRNA
Codon optimization - Next-generation codon optimization engine
myRNA is a codon optimization engine for therapeutic mRNA. It balances codon usage against RNA structural stability while handling locked regulatory regions, multiple open reading frames, degradation hotspots, restriction sites, unwanted motifs, stem-size control, and modified nucleotides. Unlike a standard codon optimizer, it treats multiple coding sequences within a single RNA as one interdependent molecule. Pair with myCONSTRUCT for amino-acid construct design and nucleotide optimization together, or use each separately.
What myRNA delivers
Codon optimization with myRNA has a turnaround time of one week:
- Multi-epitope construct design support: coding and non-coding regulatory regions are treated as a single structurally interdependent molecule
- Practical therapeutic design constraints integration: including stem size control, restriction site avoidance, and degradation hotspot mitigation
- Modified nucleotide optimization in-silico: evaluation of stability effects for pseudouridine and 5-methylcytosine
- Runtime-accuracy flexibility: rapid exploration or near-exact optimization depending on user needs, via adjustable beam width
What is myRNA?
myRNA is a codon optimization engine for therapeutic mRNA. It balances codon usage against RNA structural stability while handling locked regulatory regions, multiple open reading frames, degradation hotspots, restriction sites, unwanted motifs, stem-size control, and modified nucleotides.
How does myRNA differ from a standard codon optimizer?
A standard codon optimizer works only on the nucleotide sequence. myRNA optimizes multiple coding sequences within a single RNA as one interdependent molecule, accepts a defined codon usage bias, preserves locked regions such as UTRs and linkers, and avoids degradation hotspots, unwanted motifs, and oversized stems.
What is the turnaround time for myRNA?
Codon optimization with myRNA has a turnaround time of one week.