myCONSTRUCT
Amino acid construct optimization — Rational multi-epitope construct design
myCONSTRUCT offers rational amino acid construct design reducing unwanted junctional epitopes, minimizing unintended immunodominance, and preserving therapeutic focus. By integrating proteasomal processing, MHC presentation, immunogenicity prediction, and population-aware aggregation into a unified risk framework, myCONSTRUCT transforms string-of-beads design from heuristic assembly to predictive engineering of multi-epitope therapeutics.
What myCONSTRUCT delivers
We offer string-of-beads design optimization with a turnaround time of 1 week:
- Junctional peptide generation: enumeration of all peptide fragments that could arise across the junction following intracellular processing
- Processing and presentation modeling: evaluation of each junction for proteasomal likelihood, MHC class I (and optionally class II) presentation probability, and allele-specific binding and presentation features
- Immunogenicity scoring: estimation of the probability a presented peptide will elicit a T-cell response
- Integrated junction risk aggregation: risk score aggregation across alleles, weighted by allele frequency, and summarized at construct level
- Design optimization: order refinement, spacer selection, and construct-level junction penalty minimization
Frequently asked questions about myCONSTRUCT
What is myCONSTRUCT?
myCONSTRUCT designs multi-epitope amino acid constructs by modeling junctional peptides, processing, MHC presentation, and immunogenicity to minimize unintended immune risk.
What is the turnaround time for myCONSTRUCT?
String-of-beads design optimization with myCONSTRUCT has a turnaround time of 1 week.
Should myCONSTRUCT be used with myRNA?
Yes. myCONSTRUCT optimizes epitope order and spacers at the amino acid level; myRNA then optimizes the nucleotide sequence for RNA therapeutics.
Ready to use myCONSTRUCT?
Talk to our team about integrating myCONSTRUCT into your discovery or development workflow.